A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function

Ku heterodimer is a DNA binding protein with a prominent role in DNA repair. Here, we investigate whether and how Ku impacts the DNA damage response by acting as a post‐transcriptional regulator of gene expression. We show that Ku represses p53 protein synthesis and p53‐mediated apoptosis by binding...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Lamaa, Assala, Le Bras, Morgane, Skuli, Nicolas, Britton, Sébastien, Frit, Philippe, Calsou, Patrick, Prats, Hervé, Cammas, Anne, Millevoi, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818778/
https://ncbi.nlm.nih.gov/pubmed/26964895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541181
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