AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility

Impaired systolic function, resulting from acute injury or congenital defects, leads to cardiac complications and heart failure. Current therapies slow disease progression but do not rescue cardiac function. We previously reported that elevating the cellular 2 deoxy-ATP (dATP) pool in transgenic mic...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Kolwicz, Stephen C, Odom, Guy L, Nowakowski, Sarah G, Moussavi-Harami, Farid, Chen, Xiaolan, Reinecke, Hans, Hauschka, Stephen D, Murry, Charles E, Mahairas, Gregory G, Regnier, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817808/
https://ncbi.nlm.nih.gov/pubmed/26388461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.176
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