Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

Mutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients. Administration of recombinant adeno-associated viral vectors delivering microdystrophin or ribonucleotid...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Kolwicz, Stephen C., Hall, John K., Moussavi-Harami, Farid, Chen, Xiolan, Hauschka, Stephen D., Chamberlain, Jeffrey S., Regnier, Michael, Odom, Guy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978556/
https://ncbi.nlm.nih.gov/pubmed/31998848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.06.006
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