AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility

Impaired systolic function, resulting from acute injury or congenital defects, leads to cardiac complications and heart failure. Current therapies slow disease progression but do not rescue cardiac function. We previously reported that elevating the cellular 2 deoxy-ATP (dATP) pool in transgenic mic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther
Prif Awduron: Kolwicz, Stephen C, Odom, Guy L, Nowakowski, Sarah G, Moussavi-Harami, Farid, Chen, Xiaolan, Reinecke, Hans, Hauschka, Stephen D, Murry, Charles E, Mahairas, Gregory G, Regnier, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817808/
https://ncbi.nlm.nih.gov/pubmed/26388461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.176
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