AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility

Impaired systolic function, resulting from acute injury or congenital defects, leads to cardiac complications and heart failure. Current therapies slow disease progression but do not rescue cardiac function. We previously reported that elevating the cellular 2 deoxy-ATP (dATP) pool in transgenic mic...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Kolwicz, Stephen C, Odom, Guy L, Nowakowski, Sarah G, Moussavi-Harami, Farid, Chen, Xiaolan, Reinecke, Hans, Hauschka, Stephen D, Murry, Charles E, Mahairas, Gregory G, Regnier, Michael
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817808/
https://ncbi.nlm.nih.gov/pubmed/26388461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.176
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki