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Ribonucleotide Reductase-Mediated Increase in dATP Improves Cardiac Performance Via Myosin Activation in a Large Animal Model of Heart Failure
AIMS: Heart failure remains a leading cause of morbidity, hospitalizations and deaths. We previously showed that overexpression of the enzyme ribonucleotide reductase (RNR) in cardiomyocytes increased levels of the myosin activator, 2-deoxy-adenosine triphosphate, catalyzed enhanced contraction and...
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| Publicado no: | Eur J Heart Fail |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5523878/ https://ncbi.nlm.nih.gov/pubmed/25876005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejhf.270 |
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