Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

[Image: see text] Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a number of anticancer drugs...

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Bibliografiset tiedot
Julkaisussa:Biochemistry
Päätekijät: Ando, Nozomi, Li, Haoran, Brignole, Edward J., Thompson, Samuel, McLaughlin, Martin I., Page, Julia E., Asturias, Francisco J., Stubbe, JoAnne, Drennan, Catherine L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2015
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722859/
https://ncbi.nlm.nih.gov/pubmed/26727048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01207
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