Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase

Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in the active site of the RNR large (α2) subunit is transiently oxidized by a stab...

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Detalhes bibliográficos
Main Authors: Minnihan, Ellen C., Ando, Nozomi, Brignole, Edward J., Olshansky, Lisa, Chittuluru, Johnathan, Asturias, Francisco J., Drennan, Catherine L., Nocera, Daniel G., Stubbe, JoAnne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593893/
https://ncbi.nlm.nih.gov/pubmed/23431160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220691110
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