Tangled up in knots – Structures of inactivated forms of E. coli class Ia Ribonucleotide Reductase

Successful targets for anti-cancer drugs such as clofarabine and gemcitabine, ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α(4)β(4) rings. Here, we pres...

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Bibliographic Details
Main Authors: Zimanyi, Christina M., Ando, Nozomi, Brignole, Edward J., Asturias, Francisco J., Stubbe, JoAnne, Drennan, Catherine L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459064/
https://ncbi.nlm.nih.gov/pubmed/22727814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.05.009
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