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Tangled up in knots – Structures of inactivated forms of E. coli class Ia Ribonucleotide Reductase

Successful targets for anti-cancer drugs such as clofarabine and gemcitabine, ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α(4)β(4) rings. Here, we pres...

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書誌詳細
主要な著者: Zimanyi, Christina M., Ando, Nozomi, Brignole, Edward J., Asturias, Francisco J., Stubbe, JoAnne, Drennan, Catherine L.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459064/
https://ncbi.nlm.nih.gov/pubmed/22727814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.05.009
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