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Tangled up in knots – Structures of inactivated forms of E. coli class Ia Ribonucleotide Reductase
Successful targets for anti-cancer drugs such as clofarabine and gemcitabine, ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α(4)β(4) rings. Here, we pres...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3459064/ https://ncbi.nlm.nih.gov/pubmed/22727814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.05.009 |
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