Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers

Clofarabine (ClF) is a drug used in the treatment of leukemia. One of its primary targets is human ribonucleotide reductase (hRNR), a dual-subunit, (α(2))(m)(β(2))(n), regulatory enzyme indispensable in de novo dNTP synthesis. We report that in live mammalian cells, ClF targets hRNR by converting it...

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Detalhes bibliográficos
Main Authors: Aye, Yimon, Brignole, Edward J, Long, Marcus J C, Chittuluru, Johnathan, Drennan, Catherine L, Asturias, Francisco J, Stubbe, JoAnne
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408589/
https://ncbi.nlm.nih.gov/pubmed/22840768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.05.015
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