Transgenic overexpression of ribonucleotide reductase improves cardiac performance

We previously demonstrated that cardiac myosin can use 2-deoxy-ATP (dATP) as an energy substrate, that it enhances contraction and relaxation with minimal effect on calcium-handling properties in vitro, and that contractile enhancement occurs with only minor elevation of cellular [dATP]. Here, we re...

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Detalhes bibliográficos
Main Authors: Nowakowski, Sarah G., Kolwicz, Stephen C., Korte, Frederick Steven, Luo, Zhaoxiong, Robinson-Hamm, Jacqueline N., Page, Jennifer L., Brozovich, Frank, Weiss, Robert S., Tian, Rong, Murry, Charles E., Regnier, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625337/
https://ncbi.nlm.nih.gov/pubmed/23530224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220693110
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