Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice

Ribonucleotide reductase (RNR) is the rate-limiting enzyme in deoxyribonucleoside triphosphate (dNTP) biosynthesis, with important roles in nuclear genome maintenance. RNR is also essential for maintenance of mitochondrial DNA (mtDNA) in mammals. The mechanisms regulating mtDNA copy number in mammal...

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Bibliographic Details
Main Authors: Ylikallio, Emil, Page, Jennifer L., Xu, Xia, Lampinen, Milla, Bepler, Gerold, Ide, Tomomi, Tyynismaa, Henna, Weiss, Robert S., Suomalainen, Anu
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001089/
https://ncbi.nlm.nih.gov/pubmed/20724444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq735
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