Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

BACKGROUND: Mitochondrial DNA (mtDNA) copy number decreases in animal and human heart failure (HF), yet its role in cardiomyocytes remains to be elucidated. Thus, we investigated the cardioprotective function of increased mtDNA copy number resulting from the overexpression of human transcription fac...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ikeda, Masataka, Ide, Tomomi, Fujino, Takeo, Arai, Shinobu, Saku, Keita, Kakino, Takamori, Tyynismaa, Henna, Yamasaki, Toshihide, Yamada, Ken-ichi, Kang, Dongchon, Suomalainen, Anu, Sunagawa, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379048/
https://ncbi.nlm.nih.gov/pubmed/25822152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119687
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