Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

BACKGROUND: Mitochondrial DNA (mtDNA) copy number decreases in animal and human heart failure (HF), yet its role in cardiomyocytes remains to be elucidated. Thus, we investigated the cardioprotective function of increased mtDNA copy number resulting from the overexpression of human transcription fac...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ikeda, Masataka, Ide, Tomomi, Fujino, Takeo, Arai, Shinobu, Saku, Keita, Kakino, Takamori, Tyynismaa, Henna, Yamasaki, Toshihide, Yamada, Ken-ichi, Kang, Dongchon, Suomalainen, Anu, Sunagawa, Kenji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379048/
https://ncbi.nlm.nih.gov/pubmed/25822152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119687
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