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Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

BACKGROUND: Mitochondrial DNA (mtDNA) copy number decreases in animal and human heart failure (HF), yet its role in cardiomyocytes remains to be elucidated. Thus, we investigated the cardioprotective function of increased mtDNA copy number resulting from the overexpression of human transcription fac...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Ikeda, Masataka, Ide, Tomomi, Fujino, Takeo, Arai, Shinobu, Saku, Keita, Kakino, Takamori, Tyynismaa, Henna, Yamasaki, Toshihide, Yamada, Ken-ichi, Kang, Dongchon, Suomalainen, Anu, Sunagawa, Kenji
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379048/
https://ncbi.nlm.nih.gov/pubmed/25822152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119687
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