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2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure

We are developing a novel treatment for heart failure by increasing myocardial 2 deoxy-ATP (dATP). Our studies in rodent models have shown that substitution of dATP for adenosine triphosphate (ATP) as the energy substrate in vitro or elevation of dATP in vivo increases myocardial contraction and tha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Cell Cardiol
Prif Awduron: Moussavi-Harami, Farid, Razumova, Maria V., Racca, Alice W., Cheng, Yuanhua, Stempien-Otero, April, Regnier, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301986/
https://ncbi.nlm.nih.gov/pubmed/25498214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.12.002
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