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A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau
Synaptic spine loss is one of the major preceding consequences of stroke damages, but its underlying molecular mechanisms remain unknown. Here, we report that a direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death in a mouse model with stroke. We found that DAPK1 ph...
שמור ב:
| הוצא לאור ב: | Cereb Cortex |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4816799/ https://ncbi.nlm.nih.gov/pubmed/25995053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhv096 |
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