A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau

Synaptic spine loss is one of the major preceding consequences of stroke damages, but its underlying molecular mechanisms remain unknown. Here, we report that a direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death in a mouse model with stroke. We found that DAPK1 ph...

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Detalhes bibliográficos
Publicado no:Cereb Cortex
Main Authors: Pei, Lei, Wang, Shan, Jin, Huijuan, Bi, Linlin, Wei, Na, Yan, Honglin, Yang, Xin, Yao, Chengye, Xu, Mengmeng, Shu, Shu, Guo, Yu, Yan, Huanhuan, Wu, Jianhua, Li, Hao, Pang, Pei, Tian, Tian, Tian, Qing, Zhu, Ling-Qiang, Shang, You, Lu, Youming
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816799/
https://ncbi.nlm.nih.gov/pubmed/25995053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhv096
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