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Cas9 Functionally Opens Chromatin
Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler transcription factor retinoic acid receptor at prev...
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| Gepubliceerd in: | PLoS One |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4816323/ https://ncbi.nlm.nih.gov/pubmed/27031353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152683 |
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