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The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells

In order to efficiently edit eukaryotic genomes, it is critical to test the impact of chromatin dynamics on CRISPR/Cas9 function and develop strategies to adapt the system to eukaryotic contexts. So far, research has extensively characterized the relationship between the CRISPR endonuclease Cas9 and...

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Detalhes bibliográficos
Publicado no:ACS Synth Biol
Main Authors: Daer, René M., Cutts, Josh P., Brafman, David A., Haynes, Karmella A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357160/
https://ncbi.nlm.nih.gov/pubmed/27783893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.5b00299
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