A synergistic DNA logic predicts genome-wide chromatin accessibility

Enhancers and promoters commonly occur in accessible chromatin characterized by depleted nucleosome contact; however, it is unclear how chromatin accessibility is governed. We show that log-additive cis-acting DNA sequence features can predict chromatin accessibility at high spatial resolution. We d...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Hashimoto, Tatsunori, Sherwood, Richard I., Kang, Daniel D., Rajagopal, Nisha, Barkal, Amira A., Zeng, Haoyang, Emons, Bart J.M., Srinivasan, Sharanya, Jaakkola, Tommi, Gifford, David K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
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Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052050/
https://ncbi.nlm.nih.gov/pubmed/27456004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.199778.115
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