In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases

How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes metastases. Using primary human colon cancer cells engrafted...

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Vydáno v:J Mol Cell Biol
Hlavní autoři: Singovski, Grigori, Bernal, Carolina, Kuciak, Monika, Siegl-Cachedenier, Irene, Conod, Arwen, Ruiz i Altaba, Ariel
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816146/
https://ncbi.nlm.nih.gov/pubmed/26031752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjv034
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