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In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases

How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes metastases. Using primary human colon cancer cells engrafted...

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Dades bibliogràfiques
Publicat a:J Mol Cell Biol
Autors principals: Singovski, Grigori, Bernal, Carolina, Kuciak, Monika, Siegl-Cachedenier, Irene, Conod, Arwen, Ruiz i Altaba, Ariel
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816146/
https://ncbi.nlm.nih.gov/pubmed/26031752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjv034
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