In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases

How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes metastases. Using primary human colon cancer cells engrafted...

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Veröffentlicht in:J Mol Cell Biol
Hauptverfasser: Singovski, Grigori, Bernal, Carolina, Kuciak, Monika, Siegl-Cachedenier, Irene, Conod, Arwen, Ruiz i Altaba, Ariel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816146/
https://ncbi.nlm.nih.gov/pubmed/26031752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjv034
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