The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases

How cells in primary tumors initially become pro-metastatic is not understood. A previous genome-wide RNAi screen uncovered colon cancer metastatic suppressor and WNT promoting functions of TMED3, a member of the p24 ER-to-Golgi protein secretion family. Repression of canonical WNT signaling upon kn...

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Udgivet i:Oncogene
Main Authors: Mishra, Sonakshi, Bernal, Carolina, Silvano, Marianna, Anand, Santosh, Ruiz i Altaba, Ariel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755966/
https://ncbi.nlm.nih.gov/pubmed/31253868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0845-z
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