Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

Previous studies demonstrate the initiation of colon cancers through deregulation of WNT-TCF signalling. An accepted but untested extension of this finding is that incurable metastatic colon carcinomas (CCs) universally remain WNT-TCF-dependent, prompting the search for WNT-TCF inhibitors. CCs and t...

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Bibliographische Detailangaben
Hauptverfasser: Varnat, Frédéric, Siegl-Cachedenier, Irene, Malerba, Monica, Gervaz, Pascal, Ruiz i Altaba, Ariel
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2010
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394505/
https://ncbi.nlm.nih.gov/pubmed/20941789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201000098
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