Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

Human colon cancers often start as benign adenomas through loss of APC, leading to enhanced βCATENIN (βCAT)/TCF function. These early lesions are efficiently managed but often progress to invasive carcinomas and incurable metastases through additional changes, the nature of which is unclear. We find...

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Detalhes bibliográficos
Main Authors: Varnat, Frédéric, Duquet, Arnaud, Malerba, Monica, Zbinden, Marie, Mas, Christophe, Gervaz, Pascal, Ruiz i Altaba, Ariel
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378144/
https://ncbi.nlm.nih.gov/pubmed/20049737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900039
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