Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

Melanoma is one of the most aggressive cancers, and its incidence is increasing. These tumors derive from the melanocyte lineage and remain incurable after metastasis. Here we report that SONIC HEDGEHOG (SHH)-GLI signaling is active in the matrix of human hair follicles, and that it is required for...

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Detaylı Bibliyografya
Asıl Yazarlar: Stecca, Barbara, Mas, Christophe, Clement, Virginie, Zbinden, Marie, Correa, Rafael, Piguet, Vincent, Beermann, Friedrich, Ruiz i Altaba, Ariel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838820/
https://ncbi.nlm.nih.gov/pubmed/17392427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700776104
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