Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

Human colon cancers often start as benign adenomas through loss of APC, leading to enhanced βCATENIN (βCAT)/TCF function. These early lesions are efficiently managed but often progress to invasive carcinomas and incurable metastases through additional changes, the nature of which is unclear. We find...

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書誌詳細
主要な著者: Varnat, Frédéric, Duquet, Arnaud, Malerba, Monica, Zbinden, Marie, Mas, Christophe, Gervaz, Pascal, Ruiz i Altaba, Ariel
フォーマット: Artigo
言語:Inglês
出版事項: WILEY-VCH Verlag 2009
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378144/
https://ncbi.nlm.nih.gov/pubmed/20049737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900039
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