Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells

The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for their sustained use is the blockade of WNT si...

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Publicat a:PLoS One
Autors principals: Seth, Chandan, Mas, Christophe, Conod, Arwen, Mueller, Jens, Siems, Karsten, Kuciak, Monika, Borges, Isabel, Ruiz i Altaba, Ariel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156407/
https://ncbi.nlm.nih.gov/pubmed/27973612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168170
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