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Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis

BACKGROUND: Osteosarcoma (OS) is the most common bone malignancy in the paediatric population, principally affecting adolescents and young adults. Minimal advancements in patient prognosis have been made over the past two decades because of the poor understanding of disease biology. Runx2, a critica...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Roos, Alison, Satterfield, Laura, Zhao, Shuying, Fuja, Daniel, Shuck, Ryan, Hicks, M John, Donehower, Lawrence A, Yustein, Jason T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815801/
https://ncbi.nlm.nih.gov/pubmed/26528706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.305
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