Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis

BACKGROUND: Osteosarcoma (OS) is the most common bone malignancy in the paediatric population, principally affecting adolescents and young adults. Minimal advancements in patient prognosis have been made over the past two decades because of the poor understanding of disease biology. Runx2, a critica...

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Dettagli Bibliografici
Pubblicato in:Br J Cancer
Autori principali: Roos, Alison, Satterfield, Laura, Zhao, Shuying, Fuja, Daniel, Shuck, Ryan, Hicks, M John, Donehower, Lawrence A, Yustein, Jason T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815801/
https://ncbi.nlm.nih.gov/pubmed/26528706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.305
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