Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis

BACKGROUND: Osteosarcoma (OS) is the most common bone malignancy in the paediatric population, principally affecting adolescents and young adults. Minimal advancements in patient prognosis have been made over the past two decades because of the poor understanding of disease biology. Runx2, a critica...

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Vydáno v:Br J Cancer
Hlavní autoři: Roos, Alison, Satterfield, Laura, Zhao, Shuying, Fuja, Daniel, Shuck, Ryan, Hicks, M John, Donehower, Lawrence A, Yustein, Jason T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815801/
https://ncbi.nlm.nih.gov/pubmed/26528706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.305
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