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Protonation states and catalysis: Molecular dynamics studies of intermediates in tryptophan synthase

The importance of protonation states and proton transfer in pyridoxal 5’‐phosphate (PLP)‐chemistry can hardly be overstated. Although experimental approaches to investigate pKa values can provide general guidance for assigning proton locations, only static pictures of the chemical species are availa...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Huang, Yu‐ming M., You, Wanli, Caulkins, Bethany G., Dunn, Michael F., Mueller, Leonard J., Chang, Chia‐en A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815307/
https://ncbi.nlm.nih.gov/pubmed/26013176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2709
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