Protonation States of the Tryptophan Synthase Internal Aldimine Active Site from Solid-State NMR Spectroscopy: Direct Observation of the Protonated Schiff Base Linkage to Pyridoxal-5′-Phosphate

[Image: see text] The acid–base chemistry that drives catalysis in pyridoxal-5′-phosphate (PLP)-dependent enzymes has been the subject of intense interest and investigation since the initial identification of PLP’s role as a coenzyme in this extensive class of enzymes. It was first proposed over 50...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Caulkins, Bethany G., Bastin, Baback, Yang, Chen, Neubauer, Thomas J., Young, Robert P., Hilario, Eduardo, Huang, Yu-ming M., Chang, Chia-en A., Fan, Li, Dunn, Michael F., Marsella, Michael J., Mueller, Leonard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183654/
https://ncbi.nlm.nih.gov/pubmed/25148001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja506267d
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados