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Protonation states and catalysis: Molecular dynamics studies of intermediates in tryptophan synthase

The importance of protonation states and proton transfer in pyridoxal 5’‐phosphate (PLP)‐chemistry can hardly be overstated. Although experimental approaches to investigate pKa values can provide general guidance for assigning proton locations, only static pictures of the chemical species are availa...

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Detalles Bibliográficos
Publicado en:Protein Sci
Main Authors: Huang, Yu‐ming M., You, Wanli, Caulkins, Bethany G., Dunn, Michael F., Mueller, Leonard J., Chang, Chia‐en A.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815307/
https://ncbi.nlm.nih.gov/pubmed/26013176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2709
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