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Protonation states and catalysis: Molecular dynamics studies of intermediates in tryptophan synthase

The importance of protonation states and proton transfer in pyridoxal 5’‐phosphate (PLP)‐chemistry can hardly be overstated. Although experimental approaches to investigate pKa values can provide general guidance for assigning proton locations, only static pictures of the chemical species are availa...

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Détails bibliographiques
Publié dans:Protein Sci
Auteurs principaux: Huang, Yu‐ming M., You, Wanli, Caulkins, Bethany G., Dunn, Michael F., Mueller, Leonard J., Chang, Chia‐en A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815307/
https://ncbi.nlm.nih.gov/pubmed/26013176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2709
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