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Visualizing the Tunnel in Tryptophan Synthase with Crystallography: Insights into a Selective Filter for Accommodating Indole and Rejecting Water
Four new X-ray structures of tryptophan synthase (TS) crystallized with varying numbers of the amphipathic N-(4′-trifluoromethoxybenzoyl)-2-aminoethyl phosphate (F6) molecule are presented. These structures show one of the F6 ligands threaded into the tunnel from the β-site and reveal a distinct hyd...
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| izdano v: | Biochim Biophys Acta |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4732270/ https://ncbi.nlm.nih.gov/pubmed/26708480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.12.006 |
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