Visualizing the Tunnel in Tryptophan Synthase with Crystallography: Insights into a Selective Filter for Accommodating Indole and Rejecting Water

Four new X-ray structures of tryptophan synthase (TS) crystallized with varying numbers of the amphipathic N-(4′-trifluoromethoxybenzoyl)-2-aminoethyl phosphate (F6) molecule are presented. These structures show one of the F6 ligands threaded into the tunnel from the β-site and reveal a distinct hyd...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Hilario, Eduardo, Caulkins, Bethany G., Huang, Yu-Ming M., You, Wanli, Chang, Chia-En A., Mueller, Leonard J., Dunn, Michael F., Fan, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732270/
https://ncbi.nlm.nih.gov/pubmed/26708480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.12.006
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