טוען...
Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
Precise genome-editing relies on the repair of sequence-specific nuclease-induced DNA nicking or double-strand breaks (DSBs) by homology-directed repair (HDR). However, nonhomologous end-joining (NHEJ), an error-prone repair, acts concurrently, reducing the rate of high-fidelity edits. The identific...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4814844/ https://ncbi.nlm.nih.gov/pubmed/27030102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23549 |
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