Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing

Precise genome-editing relies on the repair of sequence-specific nuclease-induced DNA nicking or double-strand breaks (DSBs) by homology-directed repair (HDR). However, nonhomologous end-joining (NHEJ), an error-prone repair, acts concurrently, reducing the rate of high-fidelity edits. The identific...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Miyaoka, Yuichiro, Berman, Jennifer R., Cooper, Samantha B., Mayerl, Steven J., Chan, Amanda H., Zhang, Bin, Karlin-Neumann, George A., Conklin, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814844/
https://ncbi.nlm.nih.gov/pubmed/27030102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23549
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados