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Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion–Induced Kidney Growth

The molecular mechanisms underlying renal growth and renal growth–induced nephron damage remain poorly understood. Here, we report that in murine models, deletion of the tuberous sclerosis complex protein 1 (Tsc1) in renal proximal tubules induced strikingly enlarged kidneys, with minimal cystogenes...

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Podrobná bibliografie
Vydáno v:J Am Soc Nephrol
Hlavní autoři: Wu, Huijuan, Chen, Jianchun, Xu, Jinxian, Dong, Zheng, Meyuhas, Oded, Chen, Jian-Kang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814178/
https://ncbi.nlm.nih.gov/pubmed/26296742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014121264
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