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Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion–Induced Kidney Growth
The molecular mechanisms underlying renal growth and renal growth–induced nephron damage remain poorly understood. Here, we report that in murine models, deletion of the tuberous sclerosis complex protein 1 (Tsc1) in renal proximal tubules induced strikingly enlarged kidneys, with minimal cystogenes...
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| Udgivet i: | J Am Soc Nephrol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Nephrology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4814178/ https://ncbi.nlm.nih.gov/pubmed/26296742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014121264 |
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