RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins, including RNase H2. Defective RNase H2 may induce accumulation of self-nucleic acid species that trigger chronic type I interferon and inflammat...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Pokatayev, Vladislav, Hasin, Naushaba, Chon, Hyongi, Cerritelli, Susana M., Sakhuja, Kiran, Ward, Jerrold M., Morris, H. Douglas, Yan, Nan, Crouch, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813680/
https://ncbi.nlm.nih.gov/pubmed/26880576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151464
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