RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins, including RNase H2. Defective RNase H2 may induce accumulation of self-nucleic acid species that trigger chronic type I interferon and inflammat...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Pokatayev, Vladislav, Hasin, Naushaba, Chon, Hyongi, Cerritelli, Susana M., Sakhuja, Kiran, Ward, Jerrold M., Morris, H. Douglas, Yan, Nan, Crouch, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813680/
https://ncbi.nlm.nih.gov/pubmed/26880576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151464
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