Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

RNase H2 has two distinct functions: initiation of the ribonucleotide excision repair (RER) pathway by cleaving ribonucleotides (rNMPs) incorporated during DNA replication and processing the RNA portion of an R-loop formed during transcription. An RNase H2 mutant lacking RER activity but supporting...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Rep
Main Authors: Uehara, Ryo, Cerritelli, Susana M., Hasin, Naushaba, Sakhuja, Kiran, London, Mariya, Iranzo, Jaime, Chon, Hyongi, Grinberg, Alexander, Crouch, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309994/
https://ncbi.nlm.nih.gov/pubmed/30380406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.019
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares