Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

RNase H2 has two distinct functions: initiation of the ribonucleotide excision repair (RER) pathway by cleaving ribonucleotides (rNMPs) incorporated during DNA replication and processing the RNA portion of an R-loop formed during transcription. An RNase H2 mutant lacking RER activity but supporting...

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Publicado no:Cell Rep
Main Authors: Uehara, Ryo, Cerritelli, Susana M., Hasin, Naushaba, Sakhuja, Kiran, London, Mariya, Iranzo, Jaime, Chon, Hyongi, Grinberg, Alexander, Crouch, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309994/
https://ncbi.nlm.nih.gov/pubmed/30380406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.019
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