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R-loop depletion by over expressed RNase H1 in mouse B cells increases activation-induced deaminase access to the transcribed strand without altering frequency of isotype switching
R-loops, three strand structures consisting of mRNA hybridized to the complementary DNA and a single stranded DNA loop, are formed in switch regions on the heavy chain immunoglobulin locus. To determine if R-loops have a direct effect on any of the steps involved in isotype switching, we generated a...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500445/ https://ncbi.nlm.nih.gov/pubmed/28065739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.12.020 |
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