The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects

RNase H2 cleaves RNA sequences that are part of RNA/DNA hybrids or that are incorporated into DNA, thus, preventing genomic instability and the accumulation of aberrant nucleic acid, which in humans induces Aicardi-Goutières syndrome, a severe autoimmune disorder. The 3.1 Å crystal structure of huma...

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Bibliographische Detailangaben
Hauptverfasser: Figiel, Małgorzata, Chon, Hyongi, Cerritelli, Susana M., Cybulska, Magdalena, Crouch, Robert J., Nowotny, Marcin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060507/
https://ncbi.nlm.nih.gov/pubmed/21177858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.181974
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