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Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD
Human RNase H1 contains an N-terminal domain known as dsRHbd for binding both dsRNA and RNA/DNA hybrid. We find that dsRHbd binds preferentially to RNA/DNA hybrids by over 25-fold and rename it as hybrid binding domain (HBD). The crystal structure of HBD complexed with a 12 bp RNA/DNA hybrid reveals...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323259/ https://ncbi.nlm.nih.gov/pubmed/18337749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.44 |
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