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Avoidance of rNMP-induced mutations via RNaseH2 and Srs2-Exo1 dependent mechanisms
Srs2 helicase is known to dismantle nucleofilaments of the Rad51 recombinase to prevent spurious recombination events(1–3, 4, 5, 6) and unwind trinucleotide sequences that are prone to hairpin formation(7). Here we document a new, unexpected genome maintenance role of Srs2 in the suppression of muta...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140095/ https://ncbi.nlm.nih.gov/pubmed/24896181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13292 |
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