Structural basis for germline antibody recognition of HIV-1 immunogens

Efforts to elicit broadly neutralizing antibodies (bNAbs) against HIV-1 require understanding germline bNAb recognition of HIV-1 envelope glycoprotein (Env). The VRC01-class bNAb family derived from the VH1-2*02 germline allele arose in multiple HIV-1–infected donors, yet targets the CD4-binding sit...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Scharf, Louise, West, Anthony P, Sievers, Stuart A, Chen, Courtney, Jiang, Siduo, Gao, Han, Gray, Matthew D, McGuire, Andrew T, Scheid, Johannes F, Nussenzweig, Michel C, Stamatatos, Leonidas, Bjorkman, Pamela J
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Biophysics and Structural Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811768/
https://ncbi.nlm.nih.gov/pubmed/26997349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13783
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