Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P(2) to mediate tumour cell permeabilisation

Cationic antimicrobial peptides (CAPs), including taxonomically diverse defensins, are innate defense molecules that display potent antimicrobial and immunomodulatory activities. Specific CAPs have also been shown to possess anticancer activities; however, their mechanisms of action are not well def...

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Vydáno v:Oncotarget
Hlavní autoři: Phan, Thanh Kha, Lay, Fung T., Poon, Ivan K.H., Hinds, Mark G., Kvansakul, Marc, Hulett, Mark D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811302/
https://ncbi.nlm.nih.gov/pubmed/26657293
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