Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P(2) to mediate tumour cell permeabilisation

Cationic antimicrobial peptides (CAPs), including taxonomically diverse defensins, are innate defense molecules that display potent antimicrobial and immunomodulatory activities. Specific CAPs have also been shown to possess anticancer activities; however, their mechanisms of action are not well def...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Phan, Thanh Kha, Lay, Fung T., Poon, Ivan K.H., Hinds, Mark G., Kvansakul, Marc, Hulett, Mark D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811302/
https://ncbi.nlm.nih.gov/pubmed/26657293
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